1 | Alvin Kamara | 6 | NOR | New Orleans Saints vs. Minnesota Vikings, December 25, 2020 |
| Gale Sayers+ | 6 | CHI | Chicago Bears vs. San Francisco 49ers, December 12, 1965 |
| Dub Jones | 6 | CLE | Cleveland Browns vs. Chicago Bears, November 25, 1951 |
4 | Joe Mixon | 5 | CIN | Cincinnati Bengals vs. Carolina Panthers, November 6, 2022 |
| Jonathan Taylor | 5 | IND | Indianapolis Colts vs. Buffalo Bills, November 21, 2021 |
| Jamaal Charles | 5 | KAN | Kansas City Chiefs vs. Oakland Raiders, December 15, 2013 |
| Clinton Portis | 5 | DEN | Denver Broncos vs. Kansas City Chiefs, December 7, 2003 |
| Shaun Alexander | 5 | SEA | Seattle Seahawks vs. Minnesota Vikings, September 29, 2002 |
| James Stewart | 5 | JAX | Jacksonville Jaguars vs. Philadelphia Eagles, October 12, 1997 |
| Jerry Rice+ | 5 | SFO | San Francisco 49ers vs. Atlanta Falcons, October 14, 1990 |
| Kellen Winslow+ | 5 | SDG | San Diego Chargers vs. Oakland Raiders, November 22, 1981 |
| Paul Hornung+ | 5 | GNB | Green Bay Packers vs. Baltimore Colts, December 12, 1965 |
| Cookie Gilchrist | 5 | BUF | Buffalo Bills vs. New York Jets, December 8, 1963 |
| Billy Cannon | 5 | HOU | Houston Oilers vs. New York Titans, December 10, 1961 |
| Abner Haynes | 5 | DTX | Dallas Texans vs. Oakland Raiders, November 26, 1961 |
| Jim Brown+ | 5 | CLE | Cleveland Browns vs. Baltimore Colts, November 1, 1959 |
| Bob Shaw | 5 | CRD | Chicago Cardinals vs. Baltimore Colts, October 2, 1950 |
18 | Christian McCaffrey | 4 | SFO | San Francisco 49ers vs. Arizona Cardinals, October 1, 2023 |
| De'Von Achane | 4 | MIA | Miami Dolphins vs. Denver Broncos, September 24, 2023 |
| Raheem Mostert | 4 | MIA | Miami Dolphins vs. Denver Broncos, September 24, 2023 |
| Travis Kelce | 4 | KAN | Kansas City Chiefs vs. Las Vegas Raiders, October 10, 2022 |
| Leonard Fournette | 4 | TAM | Tampa Bay Buccaneers vs. Indianapolis Colts, November 28, 2021 |
| Austin Ekeler | 4 | LAC | Los Angeles Chargers vs. Pittsburgh Steelers, November 21, 2021 |
| Aaron Jones | 4 | GNB | Green Bay Packers vs. Detroit Lions, September 20, 2021 |
| Dalvin Cook | 4 | MIN | Minnesota Vikings vs. Green Bay Packers, November 1, 2020 |
| Chase Claypool | 4 | PIT | Pittsburgh Steelers vs. Philadelphia Eagles, October 11, 2020 |
| Kenyan Drake | 4 | ARI | Arizona Cardinals vs. Cleveland Browns, December 15, 2019 |
| Tevin Coleman | 4 | SFO | San Francisco 49ers vs. Carolina Panthers, October 27, 2019 |
| Marvin Jones | 4 | DET | Detroit Lions vs. Minnesota Vikings, October 20, 2019 |
| Aaron Jones | 4 | GNB | Green Bay Packers vs. Dallas Cowboys, October 6, 2019 |
| Derrick Henry | 4 | TEN | Tennessee Titans vs. Jacksonville Jaguars, December 6, 2018 |
| Todd Gurley | 4 | LAR | Los Angeles Rams vs. Seattle Seahawks, December 17, 2017 |
| Danny Woodhead | 4 | SDG | San Diego Chargers vs. Miami Dolphins, December 20, 2015 |
| Jonas Gray | 4 | NWE | New England Patriots vs. Indianapolis Colts, November 16, 2014 |
| Marshawn Lynch | 4 | SEA | Seattle Seahawks vs. New York Giants, November 9, 2014 |
| Eric Decker | 4 | DEN | Denver Broncos vs. Kansas City Chiefs, December 1, 2013 |
| Marvin Jones | 4 | CIN | Cincinnati Bengals vs. New York Jets, October 27, 2013 |
| Doug Martin | 4 | TAM | Tampa Bay Buccaneers vs. Oakland Raiders, November 4, 2012 |
| Maurice Jones-Drew | 4 | JAX | Jacksonville Jaguars vs. Tampa Bay Buccaneers, December 11, 2011 |
| Darren McFadden | 4 | OAK | Oakland Raiders vs. Denver Broncos, October 24, 2010 |
| DeAngelo Williams | 4 | CAR | Carolina Panthers vs. New York Giants, December 21, 2008 |
| DeAngelo Williams | 4 | CAR | Carolina Panthers vs. Green Bay Packers, November 30, 2008 |
| Brian Westbrook | 4 | PHI | Philadelphia Eagles vs. Arizona Cardinals, November 27, 2008 |
| Michael Turner | 4 | ATL | Atlanta Falcons vs. Carolina Panthers, November 23, 2008 |
| Ronnie Brown | 4 | MIA | Miami Dolphins vs. New England Patriots, September 21, 2008 |
| Terrell Owens+ | 4 | DAL | Dallas Cowboys vs. Washington Redskins, November 18, 2007 |
| Randy Moss+ | 4 | NWE | New England Patriots vs. Buffalo Bills, November 18, 2007 |
| Jamal Lewis | 4 | CLE | Cleveland Browns vs. Seattle Seahawks, November 4, 2007 |
| LaDainian Tomlinson+ | 4 | SDG | San Diego Chargers vs. Oakland Raiders, October 14, 2007 |
| Steven Jackson | 4 | STL | St. Louis Rams vs. Minnesota Vikings, December 31, 2006 |
| Reggie Bush | 4 | NOR | New Orleans Saints vs. San Francisco 49ers, December 3, 2006 |
| Joseph Addai | 4 | IND | Indianapolis Colts vs. Philadelphia Eagles, November 26, 2006 |
| LaDainian Tomlinson+ | 4 | SDG | San Diego Chargers vs. Denver Broncos, November 19, 2006 |
| LaDainian Tomlinson+ | 4 | SDG | San Diego Chargers vs. Cincinnati Bengals, November 12, 2006 |
| Larry Johnson | 4 | KAN | Kansas City Chiefs vs. Seattle Seahawks, October 29, 2006 |
| LaDainian Tomlinson+ | 4 | SDG | San Diego Chargers vs. San Francisco 49ers, October 15, 2006 |
| LaDainian Tomlinson+ | 4 | SDG | San Diego Chargers vs. New York Jets, November 6, 2005 |
| Shaun Alexander | 4 | SEA | Seattle Seahawks vs. Houston Texans, October 16, 2005 |
| Shaun Alexander | 4 | SEA | Seattle Seahawks vs. Arizona Cardinals, September 25, 2005 |
| T.J. Duckett | 4 | ATL | Atlanta Falcons vs. Oakland Raiders, December 12, 2004 |
| Willis McGahee | 4 | BUF | Buffalo Bills vs. Seattle Seahawks, November 28, 2004 |
| Derrick Blaylock | 4 | KAN | Kansas City Chiefs vs. Atlanta Falcons, October 24, 2004 |
| Priest Holmes | 4 | KAN | Kansas City Chiefs vs. Atlanta Falcons, October 24, 2004 |
| Joe Horn | 4 | NOR | New Orleans Saints vs. New York Giants, December 14, 2003 |
| Marcus Robinson | 4 | BAL | Baltimore Ravens vs. Seattle Seahawks, November 23, 2003 |
| Clinton Portis | 4 | DEN | Denver Broncos vs. Kansas City Chiefs, December 15, 2002 |
| Marshall Faulk+ | 4 | STL | St. Louis Rams vs. Seattle Seahawks, October 20, 2002 |
| Priest Holmes | 4 | KAN | Kansas City Chiefs vs. Cleveland Browns, September 8, 2002 |
| Marshall Faulk+ | 4 | STL | St. Louis Rams vs. Indianapolis Colts, December 30, 2001 |
| Marshall Faulk+ | 4 | STL | St. Louis Rams vs. Tampa Bay Buccaneers, December 18, 2000 |
| Marshall Faulk+ | 4 | STL | St. Louis Rams vs. Minnesota Vikings, December 10, 2000 |
| Mike Anderson | 4 | DEN | Denver Broncos vs. New Orleans Saints, December 3, 2000 |
| Fred Taylor | 4 | JAX | Jacksonville Jaguars vs. Pittsburgh Steelers, November 19, 2000 |
| Marshall Faulk+ | 4 | STL | St. Louis Rams vs. San Francisco 49ers, October 29, 2000 |
| Dorsey Levens | 4 | GNB | Green Bay Packers vs. Arizona Cardinals, January 2, 2000 |
| Isaac Bruce+ | 4 | STL | St. Louis Rams vs. San Francisco 49ers, October 10, 1999 |
| Az-Zahir Hakim | 4 | STL | St. Louis Rams vs. Cincinnati Bengals, October 3, 1999 |
| Corey Dillon | 4 | CIN | Cincinnati Bengals vs. Tennessee Oilers, December 4, 1997 |
| Harvey Williams | 4 | OAK | Oakland Raiders vs. San Diego Chargers, November 16, 1997 |
| Irving Fryar | 4 | PHI | Philadelphia Eagles vs. Miami Dolphins, October 20, 1996 |
| Rodney Hampton | 4 | NYG | New York Giants vs. New Orleans Saints, September 24, 1995 |
| Emmitt Smith+ | 4 | DAL | Dallas Cowboys vs. New York Giants, September 4, 1995 |
| Mark Ingram | 4 | MIA | Miami Dolphins vs. New York Jets, November 27, 1994 |
| Sterling Sharpe | 4 | GNB | Green Bay Packers vs. Dallas Cowboys, November 24, 1994 |
| Ronald Moore | 4 | PHO | Phoenix Cardinals vs. Los Angeles Rams, December 5, 1993 |
| Jerry Rice+ | 4 | SFO | San Francisco 49ers vs. Tampa Bay Buccaneers, November 14, 1993 |
| Sterling Sharpe | 4 | GNB | Green Bay Packers vs. Tampa Bay Buccaneers, October 24, 1993 |
| Eric Metcalf | 4 | CLE | Cleveland Browns vs. Los Angeles Raiders, September 20, 1992 |
| Thurman Thomas+ | 4 | BUF | Buffalo Bills vs. Los Angeles Rams, September 6, 1992 |
| Barry Sanders+ | 4 | DET | Detroit Lions vs. Minnesota Vikings, November 24, 1991 |
| Don Beebe | 4 | BUF | Buffalo Bills vs. Pittsburgh Steelers, September 8, 1991 |
| Emmitt Smith+ | 4 | DAL | Dallas Cowboys vs. Phoenix Cardinals, December 16, 1990 |
| Lorenzo White | 4 | HOU | Houston Oilers vs. Cleveland Browns, December 9, 1990 |
| Curt Warner | 4 | SEA | Seattle Seahawks vs. Denver Broncos, December 11, 1988 |
| Eric Dickerson+ | 4 | IND | Indianapolis Colts vs. Denver Broncos, October 31, 1988 |
| Wesley Walker | 4 | NYJ | New York Jets vs. Miami Dolphins, September 21, 1986 |
| Jimmie Giles | 4 | TAM | Tampa Bay Buccaneers vs. Miami Dolphins, October 20, 1985 |
| Daryl Turner | 4 | SEA | Seattle Seahawks vs. San Diego Chargers, September 15, 1985 |
| Larry Kinnebrew | 4 | CIN | Cincinnati Bengals vs. Houston Oilers, October 28, 1984 |
| Marcus Allen+ | 4 | RAI | Los Angeles Raiders vs. San Diego Chargers, September 24, 1984 |
| Roy Green | 4 | STL | St. Louis Cardinals vs. Seattle Seahawks, November 13, 1983 |
| Chuck Muncie | 4 | SDG | San Diego Chargers vs. Denver Broncos, November 29, 1981 |
| Earnest Gray | 4 | NYG | New York Giants vs. St. Louis Cardinals, September 7, 1980 |
| Wilbert Montgomery | 4 | PHI | Philadelphia Eagles vs. Washington Redskins, October 7, 1979 |
| Jerry Butler | 4 | BUF | Buffalo Bills vs. New York Jets, September 23, 1979 |
| Clarence Williams | 4 | SDG | San Diego Chargers vs. Buffalo Bills, September 16, 1979 |
| Roland Hooks | 4 | BUF | Buffalo Bills vs. Cincinnati Bengals, September 9, 1979 |
| Ahmad Rashad | 4 | MIN | Minnesota Vikings vs. San Francisco 49ers, September 2, 1979 |
| Earl Campbell+ | 4 | HOU | Houston Oilers vs. Miami Dolphins, November 20, 1978 |
| Terdell Middleton | 4 | GNB | Green Bay Packers vs. Seattle Seahawks, October 15, 1978 |
| Wilbert Montgomery | 4 | PHI | Philadelphia Eagles vs. Washington Redskins, September 10, 1978 |
| Wayne Morris | 4 | STL | St. Louis Cardinals vs. New Orleans Saints, October 23, 1977 |
| Chuck Foreman | 4 | MIN | Minnesota Vikings vs. Buffalo Bills, December 20, 1975 |
| O.J. Simpson+ | 4 | BUF | Buffalo Bills vs. New England Patriots, November 23, 1975 |
| Lydell Mitchell | 4 | BAL | Baltimore Colts vs. Buffalo Bills, October 12, 1975 |
| Larry Brown | 4 | WAS | Washington Redskins vs. Philadelphia Eagles, December 16, 1973 |
| Paul Warfield+ | 4 | MIA | Miami Dolphins vs. Detroit Lions, December 15, 1973 |
| Bobby Douglass | 4 | CHI | Chicago Bears vs. Green Bay Packers, November 4, 1973 |
| Harold Jackson | 4 | RAM | Los Angeles Rams vs. Dallas Cowboys, October 14, 1973 |
| Ron Johnson | 4 | NYG | New York Giants vs. Philadelphia Eagles, October 2, 1972 |
| Duane Thomas | 4 | DAL | Dallas Cowboys vs. St. Louis Cardinals, December 18, 1971 |
| Calvin Hill | 4 | DAL | Dallas Cowboys vs. Buffalo Bills, September 19, 1971 |
| Bob Hayes+ | 4 | DAL | Dallas Cowboys vs. Houston Oilers, December 20, 1970 |
| MacArthur Lane | 4 | STL | St. Louis Cardinals vs. Philadelphia Eagles, October 18, 1970 |
| Dave Williams | 4 | STL | St. Louis Cardinals vs. New Orleans Saints, November 2, 1969 |
| Ben Hawkins | 4 | PHI | Philadelphia Eagles vs. Pittsburgh Steelers, September 28, 1969 |
| Lance Alworth+ | 4 | SDG | San Diego Chargers vs. Denver Broncos, December 1, 1968 |
| Leroy Kelly+ | 4 | CLE | Cleveland Browns vs. New York Giants, December 1, 1968 |
| Roy Jefferson | 4 | PIT | Pittsburgh Steelers vs. Atlanta Falcons, November 3, 1968 |
| Donny Anderson | 4 | GNB | Green Bay Packers vs. Cleveland Browns, November 12, 1967 |
| Dan Reeves | 4 | DAL | Dallas Cowboys vs. Atlanta Falcons, November 5, 1967 |
| Bert Coan | 4 | KAN | Kansas City Chiefs vs. Denver Broncos, October 23, 1966 |
| Jim Brown+ | 4 | CLE | Cleveland Browns vs. Pittsburgh Steelers, November 28, 1965 |
| Gale Sayers+ | 4 | CHI | Chicago Bears vs. Minnesota Vikings, October 17, 1965 |
| Frank Jackson | 4 | KAN | Kansas City Chiefs vs. San Diego Chargers, December 13, 1964 |
| Art Powell | 4 | OAK | Oakland Raiders vs. Houston Oilers, December 22, 1963 |
| Mike Ditka+ | 4 | CHI | Chicago Bears vs. Los Angeles Rams, October 13, 1963 |
| John David Crow | 4 | STL | St. Louis Cardinals vs. Philadelphia Eagles, December 16, 1962 |
| Jim Brown+ | 4 | CLE | Cleveland Browns vs. St. Louis Cardinals, November 18, 1962 |
| Jim Taylor+ | 4 | GNB | Green Bay Packers vs. Philadelphia Eagles, November 11, 1962 |
| Jim Taylor+ | 4 | GNB | Green Bay Packers vs. Chicago Bears, November 4, 1962 |
| Abner Haynes | 4 | DTX | Dallas Texans vs. Boston Patriots, September 8, 1962 |
| Dick James | 4 | WAS | Washington Redskins vs. Dallas Cowboys, December 17, 1961 |
| Frank Jackson | 4 | DTX | Dallas Texans vs. Denver Broncos, December 10, 1961 |
| Jim Brown+ | 4 | CLE | Cleveland Browns vs. Philadelphia Eagles, November 19, 1961 |
| Billy Kilmer | 4 | SFO | San Francisco 49ers vs. Minnesota Vikings, October 15, 1961 |
| Jim Taylor+ | 4 | GNB | Green Bay Packers vs. Cleveland Browns, October 15, 1961 |
| Paul Hornung+ | 4 | GNB | Green Bay Packers vs. Baltimore Colts, October 8, 1961 |
| Lenny Moore+ | 4 | BAL | Baltimore Colts vs. Minnesota Vikings, October 1, 1961 |
| Lenny Moore+ | 4 | BAL | Baltimore Colts vs. Los Angeles Rams, October 16, 1960 |
| Rick Casares | 4 | CHI | Chicago Bears vs. Pittsburgh Steelers, December 6, 1959 |
| Tommy McDonald+ | 4 | PHI | Philadelphia Eagles vs. New York Giants, October 4, 1959 |
| Clarence Peaks | 4 | PHI | Philadelphia Eagles vs. Chicago Cardinals, November 16, 1958 |
| Jim Brown+ | 4 | CLE | Cleveland Browns vs. Chicago Cardinals, October 26, 1958 |
| Lenny Moore+ | 4 | BAL | Baltimore Colts vs. Chicago Bears, October 4, 1958 |
| Jim Brown+ | 4 | CLE | Cleveland Browns vs. Los Angeles Rams, November 24, 1957 |
| Willie Galimore | 4 | CHI | Chicago Bears vs. Los Angeles Rams, October 20, 1957 |
| Rick Casares | 4 | CHI | Chicago Bears vs. San Francisco 49ers, October 28, 1956 |
| Ollie Matson+ | 4 | CRD | Chicago Cardinals vs. Washington Redskins, November 21, 1954 |
| Harlon Hill | 4 | CHI | Chicago Bears vs. San Francisco 49ers, October 31, 1954 |
| Ray Mathews | 4 | PIT | Pittsburgh Steelers vs. Cleveland Browns, October 17, 1954 |
| Elroy Hirsch+ | 4 | RAM | Los Angeles Rams vs. New York Yanks, September 28, 1951 |
| Cloyce Box | 4 | DET | Detroit Lions vs. Baltimore Colts, December 3, 1950 |
| Bob Shaw | 4 | RAM | Los Angeles Rams vs. Washington Redskins, December 11, 1949 |
| Dante Lavelli+ | 4 | CLE | Cleveland Browns vs. Los Angeles Dons, October 14, 1949 |
| Don Hutson+ | 4 | GNB | Green Bay Packers vs. Detroit Lions, October 7, 1945 |
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